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Voided Urine and Bladder Wash Cytology in the Diagnosis of Bladder Cancer in Suspected Patients , Gezira Hospital for Renal Diseases and Surgery , Gezira State , Sudan (2016)

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dc.contributor.author Elboshra, Tyseer Mohamed Omer
dc.date.accessioned 2018-07-10T10:41:30Z
dc.date.available 2018-07-10T10:41:30Z
dc.date.issued 2017-03
dc.identifier.uri http://repo.uofg.edu.sd/handle/123456789/647
dc.description A Dissertation, Submitted to university of Gezira in Partial fulfillment the requirements for the Award of the Degree of MD, in,Clinical Pathology, Department of pathology - Medical laboratory, Faculty of Medicine, March 2017 en_US
dc.description.abstract Urine cytology and cystoscopy has been and remains the standard in the initial evaluation of lower urinary tract lesions to rule out bladder cancer . The study was conducted in Gezira hospital for Renal Diseases and Surgery and Medical laboratory - Faculty of medicine -University of Gezira from April to October 2016 to perform cytology of voided urine and bladder washing of patients suspected of bladder cancer . The study was a cross-sectional descriptive hospital based study. A total of 43 patients who were suspected to have bladder tumors based on both clinical and radiological findings during the study period were selected . Pre-cystoscopy voided urine specimens and post-cystoscopy bladder wash specimens were collected . Three stains were used in preparation of cytological smears Hematoxylin /Eosin, Diff-quik and May-Grünwald Giemsa , whenever possible equivalent histopathological diagnosis was obtained . The study results showed the sensitivity of urine cytology was 93.5% and specificity was 100% with high correlation between cytology and histopathology. Most of cases were transitional cell carcinoma with the same type diagnosed in biopsy. Cytology can also detect adenocarcinoma . It is less sensitive in detecting squamous cell carcinoma .Urine cytology detects high grade and low grade transitional cell carcinomas. Muscle invasive cases had the higher percentage (37.2%) with more prominent features of malignancy in cytology than the earliest stages , 30.2% of voided urine specimens were excellent , while 79.1% of bladder wash specimens had excellent quality with more cellularity and preservation of cells in cytological smears . The study concluded that voided urine and bladder wash cytology is highly sensitive and specific with 100% positive predictive value in detecting high grade and muscle invasive transitional cell carcinomas and less in detecting low grade and superficial carcinomas . en_US
dc.description.sponsorship Ahmed Abdalla Mohamedani ( Main supervisor ……………….) Sami Mahjoub Taha ( Co superviso) en_US
dc.language.iso en en_US
dc.publisher University of Gezira en_US
dc.subject cystoscopy en_US
dc.subject Renal Diseases en_US
dc.subject Medical laboratory en_US
dc.title Voided Urine and Bladder Wash Cytology in the Diagnosis of Bladder Cancer in Suspected Patients , Gezira Hospital for Renal Diseases and Surgery , Gezira State , Sudan (2016) en_US
dc.type Thesis en_US


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