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Relationship between oxidized low-density lipoprotein antibodies and obesity in different glycemic situations

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dc.contributor.author Babakr, Abdullatif Taha
dc.contributor.author Almarzouki, Abdullah A
dc.contributor.author Elsheikh, Osman Mohamed
dc.contributor.author Assiri, Adel Mohamed
dc.contributor.author Zaki, Hani Yousif
dc.contributor.author Fatani, Samir H
dc.contributor.author Mohamed, EssamEldin
dc.contributor.author Abdalla, Badr Eldin Elsonni
dc.contributor.author NourEldin
dc.date.accessioned 2017-10-28T10:34:00Z
dc.date.available 2017-10-28T10:34:00Z
dc.date.issued 2014-10-24
dc.identifier.other dx.doi.org/10.2147/DMSO.S70904
dc.identifier.uri http://repo.uofg.edu.sd/handle/123456789/433
dc.description Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy 2014:7 513–520 en_US
dc.description.abstract Background: Autoantibodies to oxidized low-density lipoprotein (oxLDL) are a heterogeneous group of antibodies that are controversially discussed to be either pathogenic or protective. Biochemical and anthropometric measurements correlated with increased levels of these antibodies are also controversial, especially in conditions of impaired glucose tolerance and type 2 diabetes mellitus. The present study was conducted to evaluate levels of oxLDL antibodies and their correlation with obesity in different glycemic situations. Methods: Two hundred and seventy-four adult males were classified into three subgroups: group 1 (n=125), comprising a control group of nondiabetic subjects; group 2 (n=77), comprising subjects with impaired glucose tolerance; and group 3 (n=72), comprising patients with type 2 diabetes mellitus. Body mass index was calculated, and measurement of oxLDL and oxLDL antibodies was performed. Results: Higher mean concentrations of oxLDL were found in the type 2 diabetes mellitus and impaired glucose tolerance groups (143.5±21.9 U/L and 108.7±23.7 U/L, respectively). The mean value for the control group was 73.5±27.5 U/L (P,0.001). Higher mean concentrations of anti-oxLDL antibodies were observed in the type 2 diabetes mellitus and impaired glucose tolerance groups (55.7±17.8 U/L and 40.4±17.6 U/L, respectively). The mean value for the control group was 20.4±10 U/L (P,0.001). Levels of anti-oxLDL antibodies were found to be positively and significantly correlated with body mass index in the control group (r=0.46), impaired glucose tolerance (r=0.51), type 2 diabetes mellitus group (r=0.46), and in the whole study population (r=0.44; P,0.001). Conclusion: Anti-oxLDL antibody levels were increased in subjects with type 2 diabetes mellitus and impaired glucose tolerance and were positively correlated with obesity and body mass index. en_US
dc.language.iso en en_US
dc.publisher Dove Medical Press Limited en_US
dc.subject anti-oxidized low-density lipoprotein antibodies en_US
dc.subject obesity en_US
dc.subject body mass index en_US
dc.subject iabetes en_US
dc.subject impaired glucose tolerance en_US
dc.title Relationship between oxidized low-density lipoprotein antibodies and obesity in different glycemic situations en_US
dc.type Article en_US


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