DSpace Repository

No Evidence for a Major Effect of Tumor Necrosis Factor Alpha Gene Polymorphisms in Periportal Fibrosis Caused by Schistosoma mansoni Infection

Show simple item record

dc.contributor.author Moukoko, Carole Eboumbou
dc.contributor.author El Wali, Nasureldin
dc.contributor.author Saeed, O. K.
dc.contributor.author Mohamed-Ali, Qurashi
dc.contributor.author Gaudart, Jean
dc.contributor.author Dessein, Alain J.
dc.contributor.author Chevillard, Christophe
dc.date.accessioned 2017-10-06T15:18:46Z
dc.date.available 2017-10-06T15:18:46Z
dc.date.issued 2003-10
dc.identifier.other DOI: 10.1128/IAI.71.10.5456–5460.2003
dc.identifier.uri http://repo.uofg.edu.sd/handle/123456789/426
dc.description.abstract Hepatic periportal fibrosis (PPF), associated with portal hypertension, is a major pathological consequence of infections with Schistosoma mansoni and Schistosoma japonicum. Indeed, affected subjects may die from portal hypertension. Previous studies have indicated that tumor necrosis factor alpha (TNF- ) may aggravate fibrosis. We therefore investigated whether PPF was associated with certain polymorphisms of the TNF- gene. Four polymorphisms (TNF- 376 G/A, 308 G/A, 238 G/A, and 488 G/A) were investigated in two Sudanese populations living in an area in which S. mansoni is endemic. These polymorphisms were analyzed for 105 Sudanese subjects with various grades of PPF, from mild to advanced; all subjects were from two neighboring villages (Taweela and Umzukra). They were then analyzed for 70 subjects with advanced liver disease and for 345 matched controls from the Gezira region. We found no evidence of associations between these four polymorphisms and PPF in both of these studies. Thus, these four polymorphisms, two of which (TNF- 376 and 308) were found to increase TNF- gene transcription, are unlikely to have a major effect on PPF progression in these populations. However, this result does not exclude the possibility that these polymorphisms have a minor effect on PPF development. en_US
dc.language.iso en en_US
dc.publisher American Society for Microbiology en_US
dc.subject Schistosoma mansoni en_US
dc.subject Periportal Fibrosis en_US
dc.subject Infections en_US
dc.subject Tumors en_US
dc.subject Sudan en_US
dc.title No Evidence for a Major Effect of Tumor Necrosis Factor Alpha Gene Polymorphisms in Periportal Fibrosis Caused by Schistosoma mansoni Infection en_US
dc.type Article en_US


Files in this item

This item appears in the following Collection(s)

Show simple item record

Search DSpace


Browse

My Account