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Formulation and Optimization of Prednisolone Dispersible Tablets

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dc.contributor.author Abdulla, Ibrahim Kamal Mohamed
dc.date.accessioned 2019-04-15T07:27:08Z
dc.date.available 2019-04-15T07:27:08Z
dc.date.issued 2018-05
dc.identifier.uri http://repo.uofg.edu.sd/handle/123456789/3656
dc.description A Dissertation Submitted to the University of Gezira in Partial Fulfillment of the Requirements for the Award of the Degree of Master of Pharmacy In Pharmaceutical Technology, Department of Pharmaceutics,Faculty of Pharmacyو May/2018 en_US
dc.description.abstract Prednisolone is an oral corticosteroid used to control asthma in both adults and children. It is available in Sudan as 5mg tablet, the adjustment of the dose for pediatric use needs crushing or cutting the tablet. As a direct consequence, children are often given formulations that have not been developed for them. This practice can compromise the efficacy and safety of the treatment. In terms of accuracy of dose and bitter taste that decrease compliance to treatment. Most companies avoid developing pediatric formulations since most of them are liquid dosage forms which present a challenge to scientist and also clinical trials involving children are governed by more stringent rules further hindering development. WHO has encouraged the development of solid dosage forms for use in pediatrics.The objective of this study was therefore to formulate prednisolone dispersible tablets which can be used in pediatrics.Taguchi Orthogonal Array Design (TOAD) was used, in which four factors namely superdisintegrant type, superdisintegrant concentration, binder type and lubricant type witch varied in three levels to obtain nine tablet formulations. The tablets were compressed after wet granulation and white tablets with an average weight of 250mg were obtained. Some post compression tests were conducted. All prepared tablets were found to be in the acceptable range. The dissolution test showed good release over 30 minutes ranging from 69.6- 70.7 % in all formulations. The optimized formula showed values of hardness of 59.00 ± 1.00 N, thickness 3.34 ± 0.13mm, weight variation within the acceptable limit (249± 2) and disintegration time of 18 seconds.The present study showed the possibility of formulating an optimized prednisolone dispersible tablets which can be further improved by adding sweetener and coloring agent to increase the acceptability of the formula by ill childern. en_US
dc.description.sponsorship Eltayeb Suliman Elamin Abbas Main Supervisor Ayman Yahia Waddad Ahmed Co-Supervisor en_US
dc.language.iso en en_US
dc.publisher University of Gezira en_US
dc.subject Pharmaceutics en_US
dc.subject Pharmaceutical Technology en_US
dc.subject Drugs en_US
dc.title Formulation and Optimization of Prednisolone Dispersible Tablets en_US
dc.type Thesis en_US

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