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Association between Estrogen Biosynthesis Enzyme CYP17 Gene Polymorphisms and Breast Cancer in Sudanese Women

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dc.contributor.author Tekle, Mihreteab Ghebretinsae
dc.date.accessioned 2018-10-22T08:50:10Z
dc.date.available 2018-10-22T08:50:10Z
dc.date.issued 2014-06-07
dc.identifier.uri http://repo.uofg.edu.sd/handle/123456789/2508
dc.description A Dissertation Submitted to University of Gezira in Partial Fulfillment of the Requirements for the Award of the Degree of Master of Science in Biochemistry Department of Biochemistry and Nutrition Faculty of Medici June - 2014 en_US
dc.description.abstract Estrogen hormones are key regulators of a wide variety of biological processes. In addition to their influence on reproduction, cell differentiation and apoptosis, they affect inflammatory response, cell metabolism and most importantly, they regulate physiological breast tissue proliferation and differentiation as well as the development and progression of breast cancer. The purpose of this study was to investigate the association between the estrogen biosynthesis enzyme encoding gene CYP17A1 polymorphisms (rs743572 and rs6162) and breast cancer in Sudanese females. This case- control study included seventy one breast cancer cases, diagnosed at National Cancer Institute –University of Gezira, Wad-Medani, Sudan in the period from January 2012 to February 2014, and seventy three healthy individuals as a control having no evidence of any personal or family history of cancer were recruited in this study. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to determine the CYP17A1 (rs743572 and rs6162) gene polymorphisms. In this study, the frequency distribution of CYP17A1 (rs743572) genotypes showed a significant association between CYP17A1 polymorphism and breast cancer (P=0.004). The CYP17A1 (rs743572) CC genotype was associated with increased risk for breast cancer (OR =1.32, 95% CI: 0.21-8.22). Women carrying C allele in CYP17A1 (rs743572) gene had 1.48-fold increased breast cancer risk. Genotype was shown to be significantly associated with breast cancer for CYP17A1 rs6162 SNP (P = 0.034). Both homoyzygous TT and heterozygotes CT genotypes were associated with decreased risk of having breast cancer compared to those with the homoyzygous CC wild type genotype. In conclusion, this study provides support that polymorphic variation in CYP17A1 rs743572 might play a role in breast cancer susceptibility, and homozygous TT carriers of the CYP17A1 rs6162 gene is inversely related to breast cancer risk in Sudanese women. The study revealed new associations of CYP17A1 (rs6162) with breast cancer risk factors which might be used as base-line new additional findings that is recommended to be investigated in a further population-based study.  en_US
dc.description.sponsorship Hani Yousif Zaki Tadros (Main Supervisor ) Areeg Saad Abdalla Faggad (Co-supervisor) en_US
dc.language.iso en en_US
dc.publisher University of Gezira en_US
dc.subject Breast Diseases en_US
dc.subject Estrogen en_US
dc.title Association between Estrogen Biosynthesis Enzyme CYP17 Gene Polymorphisms and Breast Cancer in Sudanese Women en_US
dc.type Thesis en_US


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